Lung injury in axolotl salamanders induces an organ-wide proliferation response
| Autor: | Tyler B Jensen, Peter Giunta, Timothy J Duerr, Jackson M Griffiths, James R. Monaghan, Yaa Kyeremateng, Adeleso Adesina, Natalie Grace Schultz, Hilary Wong |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell type Lung injury 03 medical and health sciences 0302 clinical medicine Axolotl medicine Animals Regeneration Lung Cell Proliferation Neuregulins biology Regeneration (biology) Mesenchymal stem cell Lung Injury respiratory system biology.organism_classification respiratory tract diseases Up-Regulation Ambystoma mexicanum 030104 developmental biology medicine.anatomical_structure Cancer research Neuregulin Blastema 030217 neurology & neurosurgery Developmental Biology Signal Transduction |
| Zdroj: | Developmental dynamics : an official publication of the American Association of AnatomistsREFERENCES. 250(6) |
| ISSN: | 1097-0177 |
| Popis: | Background Ambystoma mexicanum, the axolotl salamander, is a classic model organism used to study vertebrate regeneration. It is assumed that axolotls regenerate most tissues, but the exploration of lung regeneration has not been performed until now. Results Unlike the blastema-based response used during appendage regeneration, lung amputation led to organ-wide proliferation. Pneumocytes and mesenchymal cells responded to injury by increased proliferation throughout the injured lung, which led to a recovery in lung mass and morphology by 56 days post-amputation. Receptors associated with the Neuregulin signaling pathway were upregulated at one and 3 weeks post lung amputation. We show expression of the ligand, neuregulin, in the I/X cranial nerve that innervates the lung and cells within the lung. Supplemental administration of Neuregulin peptide induced widespread proliferation in the lung similar to an injury response, suggesting that neuregulin signaling may play a significant role during lung regeneration. Conclusion Our study characterizes axolotl lung regeneration. We show that the lung responds to injury by an organ-wide proliferative response of multiple cell types, including pneumocytes, to recover lung mass. |
| Databáze: | OpenAIRE |
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