Role of Membrane Lipids in the Regulation of Erythrocytic Oxygen-Transport Function in Cardiovascular Diseases
| Autor: | Angelina Ivanovna Seikina, Ilia N. Solomadin, Natalia V. Gromova, Victor V. Revin, Alexander Yu. Tychkov, Oksana G. Imarova, Nadezhda V. Revina, Nikolai Zhelev, Maria I. Martynova, Elvira S. Revina |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Erythrocytes Article Subject Membrane lipids Lipid Bilayers lcsh:Medicine chemistry.chemical_element Pharmacology Calcium Spectrum Analysis Raman General Biochemistry Genetics and Molecular Biology Angina Pectoris Microviscosity Hemoglobins 03 medical and health sciences medicine Humans Hypoxia Lipid bilayer General Immunology and Microbiology Chemistry lcsh:R Erythrocyte Membrane Oxygen transport Arteries General Medicine Middle Aged Hypoxia (medical) Lipids Oxygen 030104 developmental biology Membrane Biochemistry Cardiovascular Diseases Hypertension Hemoglobin Lysophospholipids medicine.symptom Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2016 (2016) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover the morphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes’ hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop. |
| Databáze: | OpenAIRE |
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