Comorbidity and intervention in octogenarians with severe symptomatic aortic stenosis
| Autor: | Pilar Carrillo, Antonio Arribas Jiménez, Ramón Andión Ogando, Sandra Vázquez, Luis Cornide, Manuel Martínez-Sellés, Carlos Rodríguez Pascual, Albert Alonso Tello, Amelia Carro Hevia, Ramón López-Palop, Domingo Sánchez-Sendin, Juan José Gómez Doblas, Maria Casares i Romeva, Xavier Borras, Tomás Ripoll Vera, Bernardo García de la Villa, Pablo Díez-Villanueva |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Poor prognosis Multivariate analysis Anciano Charlson index Comorbidity Cardiología Risk Assessment Severity of Illness Index Statistics Nonparametric Estenosis Transcatheter Aortic Valve Replacement Internal medicine Intervention (counseling) Medicine Humans Prospective Studies Registries Symptomatic aortic stenosis Geriatric Assessment Aorta Proportional Hazards Models Sistema cardiovascular Aged 80 and over Analysis of Variance Interventional treatment Acianos business.industry Aortic Valve Stenosis medicine.disease Echocardiography Doppler Surgery Survival Rate Stenosis Treatment Outcome Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Popis: | Background The benefit from intervention in elderly patients with symptomatic severe aortic stenosis (AS) and high comorbidity is unknown. Our aims were to establish the correlation between the Charlson comorbidity index and the prognosis of octogenarians with symptomatic sever AS and to identify patients who might not benefit from intervention. Methods We used the data from PEGASO (Pronóstico de la Estenosis Grave Aórtica Sintomática del Octogenario — Prognosis of symptomatic severe aortic stenosis in octogenarians), a prospective registry that included consecutively 928 patients aged ≥ 80 years with severe symptomatic AS. Results The mean Charlson comorbidity index was 3.0 ± 1.7, a total of 151 patients (16.3%) presented high comorbidity (index ≥ 5). Median survival was lower for patients with high comorbidity than for those without (16.7 ± 1.2 vs. 26.5 ± 0.6 months, p < 0.001). In patients without high comorbidity planned interventional management was clearly associated with prognosis (log rank p < 0.001), which was not the case in patients with high comorbidity (log rank p > 0.10). In multivariate analysis, the only variables that were independently associated with prognosis were planned medical management and Charlson index. Patients with high comorbidity presented non-cardiac death more frequently than those who had not (28.6% vs. 19.5%, p = 0.008). Conclusions One sixth of octogenarians with symptomatic severe AS have very high comorbidity (Charlson index ≥ 5). These patients have a poor prognosis in the short term and do not seem to benefit from interventional treatment. 4.638 JCR (2015) Q1, 24/124 Cardiac and cardiovascular systems UEM |
| Databáze: | OpenAIRE |
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