The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide
| Autor: | María Aurelia Zorrilla Zubilete, Valeria Rettori, Andrea De Laurentiis, Claudia E. Mohn, Javier Fernández-Solari, Berenice Burdet |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Lipopolysaccharides
Male AM251 medicine.medical_specialty Indoles Cannabinoid receptor Polyunsaturated Alkamides Immunology Hypothalamus Radioimmunoassay Enzyme-Linked Immunosorbent Assay Arachidonic Acids Nitric Oxide Oxytocin Depolarization-induced suppression of inhibition Rats Sprague-Dawley chemistry.chemical_compound Receptor Cannabinoid CB1 Internal medicine Cannabinoid Receptor Modulators medicine Animals Immunology and Allergy Receptor Analysis of Variance Tumor Necrosis Factor-alpha Anandamide Endocannabinoid system Rats Endocrinology Gene Expression Regulation nervous system Neurology chemistry Benzamides lipids (amino acids peptides and proteins) Carbamates Neurology (clinical) hormones hormone substitutes and hormone antagonists Endocannabinoids medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 221:32-41 |
| ISSN: | 0165-5728 |
| Popis: | article i nfo This study investigated the participation of the hypothalamic endocannabinoid system in the response to lipopolysaccharide (LPS) challenge evaluating oxytocin (OXT) and tumor necrosis factor-alpha (TNF-a) plasma levels in vivo and their release from hypothalamic fragments in vitro. LPS increased OXT and TNF-α release through anandamide-activation of hypothalamic cannabinoid receptor CB1, since the antagonist AM251 blocked this effect. Anandamide, through its receptors, also increased hypothalamic nitric oxide (NO) which inhibited OXT release, ending the stimulatory effect of the endocannabinoid. Our findings reveal a hypothalamic interaction between oxytocin, endocannabinoid and NO-ergic systems providing a regulation of the hypothalamic-neurohypophyseal axis under basal and stress conditions. |
| Databáze: | OpenAIRE |
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