Interaction between indomethacin and heavy metal ions in aqueous solution
| Autor: | Adamo Fini, Giorgio Feroci, G. Fazio |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Cadmium Aqueous solution Metal ions in aqueous solution Anti-Inflammatory Agents Non-Steroidal Indomethacin Inorganic chemistry Water Pharmaceutical Science chemistry.chemical_element Salt (chemistry) Zinc Copper Metal Solubility chemistry Metals Heavy visual_art visual_art.visual_art_medium Calcium Drug Interactions |
| Zdroj: | European Journal of Pharmaceutical Sciences. 13:213-217 |
| ISSN: | 0928-0987 |
| Popis: | The interaction between indomethacin anions and heavy metal ions, such as cadmium, zinc and copper(II) ions, was studied in aqueous solution by polarographic techniques. Indomethacin anions form complexes with these heavy metal ions: the complex formed with cadmium ions is sparingly soluble, while more soluble and also stronger complexes are formed with zinc and copper(II). At high concentrations, where indomethacin anions undergo self-aggregation, these last compounds are solubilised. This property is briefly discussed and compared to that of bile salts. In the presence of calcium ions, indomethacin forms a poorly soluble salt and no evidence was detected for the formation of complex species. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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