CD8 expression in a case of chronic lymphocytic leukemia with trisomy 12
| Autor: | Mariano Scolnik, Carlos Galmarini, María Fernanda Palacios, María Carolina Bayo Hanza, Marcela Sarmiento, Christian Chena, Ricardo Dourisboure, Irma Slavutsky, Maria M.E. de Bracco |
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| Předmět: |
Male
CD20 medicine.medical_specialty Chromosomes Human Pair 12 biology CD8 Antigens Chronic lymphocytic leukemia Cytogenetics Aneuploidy Trisomy Hematology General Medicine medicine.disease Leukemia Lymphocytic Chronic B-Cell Antigen hemic and lymphatic diseases Immunology medicine biology.protein Cancer research Humans Hairy cell leukemia CD8 Aged |
| Zdroj: | Scopus-Elsevier |
| Popis: | We report a case of B-cell chronic lymphocytic leukemia (B-CLL) with aberrant expression of the T-cell-associated antigen CD8, as revealed by two-color flow-cytometric analysis. DNA studies showed immunoglobulin heavy-chain gene rearrangement, but not of γ-chain T-cell receptor, confirming the B-cell origin of the neoplastic cells. Ploidy analysis showed a tetraploid population and high S-phase fraction. B-CLL cells also carried trisomy 12, detected by fluorescence in situ hybridization. The identification of more cases with the same features would be necessary to establish the prognosis of this subtype of B-CLL. |
| Databáze: | OpenAIRE |
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