| Autor: |
Genia R. Bercovitz, Annora M. Gaerig, Emily D. Conway, Jane Ashley Huey, Mary R. Telle, Renata Stavinohova, Giunio Bruto Cherubini, Angelo Capasso, Kathern E. Myrna |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of the American Veterinary Medical Association. :1-7 |
| ISSN: |
0003-1488 |
| DOI: |
10.2460/javma.22.07.0301 |
| Popis: |
OBJECTIVE To characterize the clinical course and long-term prognosis of a suspected novel cause of neurogenic keratoconjunctivitis sicca (nKCS) secondary to florfenicol, terbinafine hydrochloride, mometasone furoate (Claro and Neptra) or florfenicol, terbinafine, betamethasone acetate (Osurnia). ANIMALS 29 client-owned dogs. PROCEDURES Online survey and word-of-mouth recruitment were conducted to identify dogs that developed clinical signs of nKCS after application of otitis externa medication containing terbinafine and florfenicol. A retrospective analysis of medical records of dogs meeting inclusion criteria was then conducted. Included dogs had onset of clinical signs of nKCS within 1 day after application of otitis externa medications containing terbinafine and florfenicol and had documentation of low Schirmer tear test value (< 15 mm/min) of affected eyes. RESULTS 29 dogs with medical records available for review met the inclusion criteria. Documented return of clinically normal tear production was identified in 24 of 29 dogs, with a median time from application of ear medication to documented return of clinically normal tear production of 86 days (range, 19 to 482 days). A corneal ulcer was diagnosed in 68% (20/29). Multivariable Cox regression analysis showed being referred to an ophthalmologist (P = .03) and having a deep ulcer (P = .02) were associated with a longer time to documentation of Schirmer tear test ≥ 15 mm/min. CLINICAL RELEVANCE Dogs that developed nKCS within 1 day after application of otitis externa medications containing terbinafine and florfenicol had a good prognosis for return of normal tear production within 1 year. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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