Epirubicin and docetaxel as neoadjuvant treatment of hormone receptor positive, HER-2 negative breast cancer: findings from two successive phase II studies
| Autor: | Manuela La Grassa, Alessandro Tuzi, Samuele Massarut, Loredana Militello, Diana Crivellari, Tiziana Perin, Davide Lombardi, Andrea Veronesi |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Chemotherapy business.industry medicine.medical_treatment medicine.disease epirubicin Gastroenterology Surgery Radiation therapy breast cancer Breast cancer Oncology Docetaxel Internal medicine Mucositis docetaxel Medicine Radiology Nuclear Medicine and imaging Hormone therapy Progression-free survival business Research Article neoadjuvant chemotherapy medicine.drug Epirubicin |
| Zdroj: | Radiology and Oncology |
| ISSN: | 1581-3207 1318-2099 |
| Popis: | Background. We report on the activity of the combination of epirubicin and docetaxel given in neoadjuvant setting for 4 and 8 cycles respectively in 2 successive series of patients with large operable or locally advanced, hormone receptor positive, HER-2 negative breast cancer. Patients and methods. Patients were treated from 2002 to 2006 with epirubicin 90 mg/m2 and docetaxel 75 mg/ m2 intravenously, every 3 weeks for 4 cycles before and 4 cycles after surgery (Series I - 13 patients), and from 2006 to 2010 with the same regimen administered for 8 cycles preoperatively (Series II - 37 patients), plus hormonal therapy for 5 years and radiation therapy if indicated. All Series I and 32 Series II patients were able to complete the preoperative chemotherapy. Results. A complete response was found in 1 patient from Series I and 13 patients from Series II and the partial remission in 10 patients from Series I and 21 patients from Series II. Two Series I and 3 Series II patients did not respond clinically. Response rate (Series I/Series II) was 84/92%. All 50 patients underwent surgery. In Series I patients, 3 pCR occurred in the breast and the axilla was histologically negative in 2 cases. No evidence of disease both in the breast and in the axilla was achieved in 7.6% (1/13) of patients. In Series II patients, 8 pCR occurred in the breast and axilla was histologically negative in 15 patients. No evidence of disease both in the breast and in the axilla occurred in 10.8% (4/37) of patients. G3-G4 toxicity included myelosuppression in 3 patients from Series I and all patients from Series II, and mucositis in 1 patient from Series I and 4 patients from series II. No other G3-4 toxicities or toxic deaths occurred. Five-year progression free survival was 38% and 90% in Series I and Series II patients respectively. Conclusions. The incidence of pathologic complete remissions was lower in our patient population, compared to reported data. A longer duration of the preoperative treatment might be associated with a longer progression-free survival. |
| Databáze: | OpenAIRE |
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