Vagal postganglionic origin of vasoactive intestinal polypeptide (VIP) mediating the vagal tachycardia
| Autor: | H. M. Snow, F. Markos |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Tachycardia
Bradycardia Cardiac Catheterization medicine.medical_specialty Physiology Adrenergic beta-Antagonists Vasoactive intestinal peptide Blood Pressure Stimulation chemistry.chemical_compound Dogs Heart Rate Physiology (medical) Internal medicine Animals Medicine Orthopedics and Sports Medicine cardiovascular diseases Receptor business.industry digestive oral and skin physiology Public Health Environmental and Occupational Health Vagus Nerve General Medicine Atenolol Coronary Vessels Electric Stimulation Atropine Endocrinology chemistry cardiovascular system Receptors Vasoactive Intestinal Peptide Ganglia Hexamethonium medicine.symptom business hormones hormone substitutes and hormone antagonists Vasoactive Intestinal Peptide medicine.drug |
| Zdroj: | European Journal of Applied Physiology. 98:419-422 |
| ISSN: | 1439-6327 1439-6319 |
| DOI: | 10.1007/s00421-006-0270-1 |
| Popis: | Our aim was to confirm the role of postganglionic vagal fibres and vasoactive intestinal polypeptide (VIP) in mediating the vagal tachycardia in anaesthetised dogs. Vagal postganglionic stimulation after atenolol (1 mg/kg) and hexamethonium (10 mg/kg) caused a bradycardia (40 beats/min, n = 2), after atropine (0.5 mg/kg i.v.) the resulting tachycardia (37 beats/min) was attenuated by VIP receptor antagonism with VIP (6-28) (100 mug i.c.) by approximately 50%. VIP release from vagal postganglionic fibres mediates the vagal tachycardia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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