Stereocontrolled Total Synthesis of the Potent Anti-inflammatory and Pro-resolving Lipid Mediator Resolvin D3 and Its Aspirin-Triggered 17R-Epimer
| Autor: | Nicos A. Petasis, Jeremy W. Winkler, Jasim Uddin, Charles N. Serhan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Aspirin
Molecular Structure Stereochemistry Chemistry medicine.drug_class Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Total synthesis Stereoisomerism Lipid metabolism Lipid signaling Lipid Metabolism Biochemistry Article Anti-inflammatory chemistry.chemical_compound Docosahexaenoic acid Fatty Acids Unsaturated medicine Epimer Inflammation Mediators Physical and Theoretical Chemistry Resolvin |
| Zdroj: | Organic Letters. 15:1424-1427 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | The first total synthesis of stereochemically pure resolvin D3 and aspirin-triggered resolvin D3 is reported. These enzymatic metabolites of docosahexaenoic acid (DHA) have potent anti-inflammatory and pro-resolving actions. The convergent synthetic strategy is based on enantiomerically pure starting materials, and it is highly stereocontrolled. |
| Databáze: | OpenAIRE |
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