| Autor: |
Neil Murphy, Christina C Newton, Mingyang Song, Nikos Papadimitriou, Michael Hoffmeister, Amanda I Phipps, Tabitha A Harrison, Polly A Newcomb, Elom K Aglago, Sonja I Berndt, Hermann Brenner, Daniel D Buchanan, Yin Cao, Andrew T Chan, Xuechen Chen, Iona Cheng, Jenny Chang-Claude, Niki Dimou, David Drew, Alton B Farris, Amy J French, Steven Gallinger, Peter Georgeson, Marios Giannakis, Graham G Giles, Stephen B Gruber, Sophia Harlid, Li Hsu, Wen-Yi Huang, Mark A Jenkins, Ruhina S Laskar, Loic Le Marchand, Paul Limburg, Yi Lin, Marko Mandic, Johnathan A Nowak, Mereia Obón-Santacana, Shuji Ogino, Conghui Qu, Lori C Sakoda, Robert E Schoen, Melissa C Southey, Zsofia K Stadler, Robert S Steinfelder, Wei Sun, Stephen N Thibodeau, Amanda E Toland, Quang M Trinh, Kostas K Tsilidis, Tomotaka Ugai, Bethany Van Guelpen, Xiaoliang Wang, Michael O Woods, Syed H Zaidi, Marc J Gunter, Ulrike Peters, Peter T Campbell |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Background Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease. Methods We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11 872 CRC cases and 11 013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables. Results Higher BMI was associated with increased CRC risk (OR per 5 kg/m2 = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control). Conclusions In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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