Distinct Roles of Endothelial Dysfunction and Inflammation in Intracranial Atherosclerotic Stroke
| Autor: | Gyeong-Moon Kim, Kwang Ho Lee, Gyeong Joon Moon, Oh Young Bang, Jong-Won Chung, Chin-Sang Chung, Yeon Hee Cho, Mi Jeong Oh |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Intracranial stenosis Inflammation 030204 cardiovascular system & hematology Arginine 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Endothelium Endothelial dysfunction Stroke Aged business.industry Middle Aged Intracranial Arteriosclerosis medicine.disease Neurology 1-Alkyl-2-acetylglycerophosphocholine Esterase Ischemic stroke Cardiology Female Neurology (clinical) medicine.symptom business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | European Neurology. 77:211-219 |
| ISSN: | 1421-9913 0014-3022 |
| DOI: | 10.1159/000460816 |
| Popis: | Background/Aims: The aim of the study was to evaluate the differential roles of endothelial dysfunction and inflammation in intracranial atherosclerotic stroke (ICAS). Methods: We prospectively recruited 262 patients with acute cerebral infarcts caused by ICAS and 75 individuals with no history of stroke as controls. Markers of endothelial dysfunction (asymmetric dimethylarginine, ADMA) and inflammation (lipoprotein-associated phospholipase A2, Lp-PLA2) were measured. Acute ischemic lesions were measured in terms of their size, composition, and patterns. Subclinical microangiopathy (degree of leukoaraiosis) and macroangiopathy (presence/number of asymptomatic stenoses) were graded in each patient. Results: Compared to normal controls, serum levels of ADMA (0.69 ± 0.14 vs. 0.47 ± 0.10, p < 0.001) and Lp-PLA2 (138.1 ± 116.8 vs. 19.0 ± 58.0, p < 0.001) were elevated in patients with ICAS. A high ADMA serum level was associated with greater prevalence of preclinical microangiopathy and macroangiopathy. Contrastingly, an elevated serum Lp-PLA2 level was associated with larger ischemic lesions, a greater number of lesions, and a larger cortical pattern. Conclusions: Endothelial dysfunction and inflammation have distinct effects in ICAS patents; endothelial dysfunction is associated with the underlying micro- and macro-atherosclerotic burden, whereas inflammation is associated with acute infarct volume and pattern. |
| Databáze: | OpenAIRE |
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