A review on the use of hyaluronic acid in tympanic membrane wound healing

Autor: Marcus D. Atlas, Bing Mei Teh, Robert J. Marano, Peter L. Friedland, Yi Shen
Rok vydání: 2011
Předmět:
Zdroj: Expert Opinion on Biological Therapy. 12:23-36
ISSN: 1744-7682
1471-2598
DOI: 10.1517/14712598.2012.634792
Popis: Tympanic membrane perforation represents a significant morbidity, especially if it occurs during a child's speech and language development. Recently, there has been an increased interest in hyaluronic-acid-related research and products as a potential therapeutic option for tympanic membrane perforation repair.This review describes the physical and chemical properties of hyaluronic acid and examines the role of hyaluronic acid in wound healing, in particular on the tympanic membrane. It also reviews the safety and efficacy of hyaluronic acid and its derivatives in animal studies as well as in clinical trials. Finally, it considers the potential future clinical applications in tympanic membrane perforation repair.Hyaluronic acid has been found to accelerate tympanic membrane perforation closure, shorten the period of healing, produce a better quality neo-membrane and improve hearing. More importantly, hyaluronic acid is biodegradable, safe and biocompatible in the ear. Recently, there has been a trend towards the use of modified hyaluronic acid. However, there is a lack of higher-level evidence to support the use of hyaluronic acid in tympanic membrane perforations in the clinical setting. More large-scale randomised control trials are warranted before these bio-devices will be used routinely.
Databáze: OpenAIRE