Mg 2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D
| Autor: | Amber N. Shatzer, Gulbu Uzel, Stefania Pittaluga, Rebecca A. Marsh, Feng-Yen Li, Jack J. Bleesing, Jeffrey I. Cohen, Ping Jiang, Timothy Jancel, Geraldine M. O’Connor, Helen F. Matthews, Huseyin Mehmet, Michael J. Lenardo, Taco W. Kuijpers, Matthew Biancalana, Kim E. Nichols, Benjamin Chaigne-Delalande, Sunil Nagpal, Marshall J. Lukacs, Lixin Zheng, Helen C. Su, Carrie L. Lucas |
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| Přispěvatelé: | AII - Amsterdam institute for Infection and Immunity, Paediatric Infectious Diseases / Rheumatology / Immunology |
| Rok vydání: | 2013 |
| Předmět: |
Cytotoxicity
Immunologic Epstein-Barr Virus Infections XMEN disease chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Biology X-Linked Combined Immunodeficiency Diseases Article Virus In vivo hemic and lymphatic diseases medicine Humans Cytotoxic T cell Magnesium Cation Transport Proteins Multidisciplinary medicine.disease NKG2D Molecular biology Killer Cells Natural Cytolysis NK Cell Lectin-Like Receptor Subfamily K Immunology Magnesium Deficiency Intracellular CD8 |
| Zdroj: | Science, 341(6142), 186-191. American Association for the Advancement of Science |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Magnesium to the Rescue Individuals with X-linked immunodeficiency with Mg 2+ defect, Epstein-Barr virus (EBV) infection, and neoplasia (XMEN) disease are genetically deficient for expression of MAGT1 , a magnesium transporter. Chaigne-Delalande et al. (p. 186 ) sought to better understand why these individuals are chronically infected with EBV at high viral loads and are susceptible to the development of lymphomas. CD8 + T cells and natural killer cells, which help to keep EBV infection in check, exhibited reduced cytotoxicity owing to their lower expression of the cell surface receptor NKG2D, which triggers cytolysis upon ligation. Magnesium supplementation in vitro and also in two XMEN patients restored levels of free Mg 2+ , increased NKG2D expression, and resulted in reduced amounts of EBV + cells, suggesting that this may be an effective therapeutic approach for XMEN patients. |
| Databáze: | OpenAIRE |
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