Dopaminergic drug effects on probability weighting during risky decision making
| Autor: | Mahur M. Hashemi, Lieneke Janssen, Karita E. Ojala, Roshan Cools, Monique H.M. Timmer, Guillaume Sescousse, Dirk E. M. Geurts, Niels ter Huurne |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Behavioral addiction 230 Affective Neuroscience Adolescent Dopamine Decision Making Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Rational planning model Young Adult All institutes and research themes of the Radboud University Medical Center Risk-Taking Double-Blind Method Reward Prospect theory Dopamine receptor D3 Dopamine receptor D2 medicine Humans Probability General Neuroscience pathological gambling Dopaminergic prospect theory General Medicine New Research Middle Aged Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] 1.1 Weighting Cognition and Behavior risky decision making Gambling Dopamine Antagonists Sulpiride medicine.symptom probability weighting Psychology 170 000 Motivational & Cognitive Control medicine.drug Cognitive psychology |
| Zdroj: | eNeuro eNeuro, 5, 2, pp. eNeuro, 5, |
| ISSN: | 2373-2822 |
| Popis: | Dopamine has been associated with risky decision-making, as well as with pathological gambling, a behavioral addiction characterized by excessive risk-taking behavior. However, the specific mechanisms through which dopamine might act to foster risk-taking and pathological gambling remain elusive. Here we test the hypothesis that this might be achieved, in part, via modulation of subjective probability weighting during decision making. Human healthy controls (n= 21) and pathological gamblers (n= 16) played a decision-making task involving choices between sure monetary options and risky gambles both in the gain and loss domains. Each participant played the task twice, either under placebo or the dopamine D2/D3receptor antagonist sulpiride, in a double-blind counterbalanced design. A prospect theory modelling approach was used to estimate subjective probability weighting and sensitivity to monetary outcomes. Consistent with prospect theory, we found that participants presented a distortion in the subjective weighting of probabilities, i.e., they overweighted low probabilities and underweighted moderate to high probabilities, both in the gain and loss domains. Compared with placebo, sulpiride attenuated this distortion in the gain domain. Across drugs, the groups did not differ in their probability weighting, although gamblers consistently underweighted losing probabilities in the placebo condition. Overall, our results reveal that dopamine D2/D3receptor antagonism modulates the subjective weighting of probabilities in the gain domain, in the direction of more objective, economically rational decision making. |
| Databáze: | OpenAIRE |
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