Inhibition of N- and P/Q-type Ca2+channels by cannabinoid receptors in single cerebrocortical nerve terminals
| Autor: | Magdalena Torres, María del Carmen Godino, José Sánchez-Prieto |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Cannabinoid receptor Morpholines medicine.medical_treatment Biophysics Naphthalenes Biochemistry Structural Biology Genetics medicine Animals Rats Wistar Receptors Cannabinoid Receptor Cannabinoid Molecular Biology Ion transporter Cerebral Cortex Nerve Endings Calcium metabolism Ion Transport Ca2+ channel Chemistry Ca2+ imaging in single nerve terminal Glutamate receptor Cell Biology Benzoxazines Rats medicine.anatomical_structure Cerebral cortex Metabotropic glutamate receptor Calcium Calcium Channels Glutamate release |
| Zdroj: | FEBS Letters. 579:768-772 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2004.12.065 |
| Popis: | Since cannabinoid receptors inhibit excitatory synaptic transmission by reducing glutamate release, we have examined whether this might occur through the direct inhibition of presynaptic Ca2+ channels. In cerebrocortical nerve terminals, activation of cannabinoid receptors with WIN55,212-2 reduces the KCl-evoked release of glutamate. However, this inhibition is attenuated when N- and P/Q-type Ca2+ channels are blocked. Through Ca2+ imaging in single nerve terminals, we found that WIN55,212-2 reduced the influx of Ca2+ both in nerve terminals that contain N-type Ca2+ channels and those that contain P/Q-type Ca2+ channels. Thus, cannabinoid receptors modulate the two major Ca2+ channels coupled to glutamate release in the cerebral cortex. |
| Databáze: | OpenAIRE |
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