Vitamin D in gynecological diseases
| Autor: | Li-Chun Liu, Ta-Wei Chu, Jing-Yun Jhao, Huan-Shuo Chang, Ta-Jen Lin, Tzu-Wei Lin, Chia-Lin Wang, Cheng-Chang Chang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Adolescent business.industry Taiwan Endometriosis HPV infection General Medicine Odds ratio Vitamin D Deficiency medicine.disease Risk Assessment Gastroenterology vitamin D deficiency Young Adult medicine.anatomical_structure Abnormal PAP Smear Internal medicine Cohort medicine Vitamin D and neurology Humans Female business Genital Diseases Female Cervix |
| Zdroj: | Journal of the Chinese Medical Association. 84:1054-1059 |
| ISSN: | 1726-4901 |
| DOI: | 10.1097/jcma.0000000000000607 |
| Popis: | BACKGROUND Most reproductive system studies suggest the protective effects of vitamin D, but vitamin D deficiency and insufficiency are growing global health issues. The present study investigates the association between vitamin D deficiency/insufficiency and gynecologic diseases to identify illness risks at different serum vitamin D levels in Taiwan. METHODS A total of 7699 female adults aged ≥20 years with results for both serum vitamin D and gynecologic-associated diseases were drawn from the Taiwan MJ cohort. We analyzed the correlation between serum vitamin D levels and results from reproductive system evaluations, including history of dysmenorrhea, results of Pap smear, high-risk human papillomavirus (HPV) infection of the cervix, mammography, and ultrasound of breast and pelvis. RESULTS Over 80% of participants showed vitamin D deficiency/insufficiency. Participants with abnormal Pap smear results, high-risk HPV infection, and history of dysmenorrhea showed significantly lower levels of serum vitamin D (p < 0.001-0.05). Serum vitamin D deficiency was significantly associated with positive high-risk HPV infection of the cervix (p < 0.05) and dysmenorrhea (p < 0.001). After controlling for age as a confounding variable for each gynecologic disease, level of serum vitamin D was significantly associated with abnormal breast ultrasound (odds ratio = 0.724) and uterus ultrasound (odds ratio = 0.673 - 0.8), and dysmenorrhea (odds ratio = 0.829). CONCLUSION Associations were found between vitamin D deficiency and endometriosis, uterine myoma, dysmenorrhea, abnormal Pap smear results, and high-risk HPV infection of the cervix. Therefore, vitamin D supplements may present a cost-effective benefit for the prevention and treatment of gynecologic diseases, and thus reduction of healthcare expenditures. |
| Databáze: | OpenAIRE |
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