Comparative study of chemoembolization loadable beads: in vitro drug release and physical properties of DC bead and hepasphere loaded with doxorubicin and irinotecan
| Autor: | Alban Denys, Olivier Jordan, Eric Doelker, Thierry de Baere, Nathalie Boulens |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Drug Compounding/methods Drug Compounding Capsules Camptothecin/analogs & derivatives/chemistry Irinotecan Microsphere Absorption Diffusion Hardness Delayed-Action Preparations/chemistry Medicine Radiology Nuclear Medicine and imaging Doxorubicin Antineoplastic Agents Phytogenic/chemistry Spherical shape ddc:615 Chromatography Antibiotics Antineoplastic business.industry Doxorubicin/chemistry Antineoplastic Agents Phytogenic Embolization Therapeutic digestive system diseases In vitro Surgery Drug Combinations Homogeneous Delayed-Action Preparations Antineoplastic/chemistry Drug release Camptothecin Capsules/chemistry Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Vascular and Interventional Radiology, Vol. 21, No 7 (2010) pp. 1084-90 |
| ISSN: | 1535-7732 |
| Popis: | Purpose To characterize in vitro the loadability, physical properties, and release of irinotecan and doxorubicin from two commercially available embolization microspheres. Materials and Methods DC Bead (500–700 μm) and Hepasphere (400–600 μm) microspheres were loaded with either doxorubicin or irinotecan solutions. Drug amount was quantified with spectrophotometry, bead elasticity was measured under compression, and bead size and loading homogeneity were assessed with microscopy image analysis. Drug release was measured over 1-week periods in saline by using a pharmacopeia flow-through method. Results Almost complete drug loading was obtained for both microsphere types and drugs. Doxorubicin-loaded DC Beads maintained their spherical shape throughout the release. In contrast, Hepaspheres showed less homogeneous doxorubicin loading and, after release, some fractured microspheres. Incomplete doxorubicin release was observed in saline over 1 week (27% ± 2 for DC beads and 18% ± 7 for Hepaspheres; P = .013). About 75% of this amount was released within 2.2 hours for both beads. For irinotecan, complete release was obtained for both types of beads, in a sustained manner over 2–3 hours for DC Beads, and in a significantly faster manner as a 7-minute burst for Hepaspheres. Conclusions The two drug-eluting microspheres could be efficiently loaded with both drugs. Incomplete doxorubicin release was attributed to strong drug-bead ionic interactions. Weaker interactions were observed with irinotecan, which led to faster drug release. |
| Databáze: | OpenAIRE |
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