Assessment of microRNA-144-5p and its putative targets in inflamed gingiva from chronic periodontitis patients
| Autor: | Jianjia Li, Yihong Ge, Fuchun Fang, Danhong Chen, Buling Wu, Runting Wang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Gingiva Gene Expression Inflammation Biology Pathogenesis 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation microRNA medicine Humans Molecular Targeted Therapy Gene Periodontitis Interleukin-17 Gene Transfer Techniques 030206 dentistry Middle Aged medicine.disease Chronic periodontitis Up-Regulation MicroRNAs 030104 developmental biology Cyclooxygenase 2 Chronic Periodontitis Cancer research Periodontics Female medicine.symptom DNA microarray |
| Zdroj: | Journal of periodontal research. 54(3) |
| ISSN: | 1600-0765 |
| Popis: | BACKGROUND AND OBJECTIVE This study aimed to discover the distinctive MicroRNAs (miRNA) functioning in the pathogenesis of periodontal inflammation, which might be potential therapy targets of chronic periodontitis. MATERIAL AND METHODS miRNA profiles of human inflamed gingival tissue from three previous microarrays were re-analysed. Gingival tissues were collected for the validation of overlapping miRNAs, and a network was constructed to show regulatory connection between overlapping miRNAs and periodontitis-associated target genes. Potential miRNAs were screened based on their expression levels and predicted target genes. Correlation analysis and binding site prediction were conducted to reveal the relationship between the potential miRNAs and their target genes. RESULTS miR-144-5p, found to be upregulated in all three studies, showed the greatest upregulation (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text