Cefazolin-Associated INR Elevation: A Case Report
| Autor: | Jeremiah L. Barnes, Inez E. Pabian, Abigail K. Bonjour, Karolyn A. Mosbacher, Grace C. Mortrude, Kyle A. Beasley |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of pharmacy practice. |
| ISSN: | 1531-1937 |
| Popis: | Purpose To describe a case of significantly elevated international normalized ratio (INR) in a patient on apixaban receiving treatment with intravenous cefazolin in the setting of coronavirus disease 2019 (COVID-19) infection and malnutrition. Summary A 74-year-old male patient on apixaban receiving cefazolin for osteomyelitis in the setting of COVID-19 and poor nutritional intake presented with internal jugular tunneled catheter site bleeding and an INR of greater than 22.5. Laboratory abnormalities and bleeding concerns were successfully managed with vitamin K and changing antimicrobial therapy from cefazolin to daptomycin. Follow-up labs one week later demonstrated a sustained improvement in coagulopathy. Conclusion INR prolongation believed to be secondary to cefazolin can be effectively managed with administration of vitamin K and conversion of antimicrobial therapy to an alternative agent. |
| Databáze: | OpenAIRE |
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