A newly detected tick-borne encephalitis (TBE) focus in south-east Sweden: A follow-up study of TBE virus (TBEV) seroprevalence
| Autor: | Louise Stjernberg, Karin Holmkvist, Johan Berglund |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Microbiology (medical) Adolescent Endemic Diseases Tbe virus Tick Encephalitis Viruses Tick-Borne Serology Seroepidemiologic Studies parasitic diseases Prevalence South east Humans Medicine Seroprevalence Child Aged Aged 80 and over Sweden General Immunology and Microbiology biology business.industry Age Factors Follow up studies Tick-borne encephalitis General Medicine Middle Aged bacterial infections and mycoses biology.organism_classification medicine.disease Virology Infectious Diseases Female business Encephalitis Tick-Borne Encephalitis |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 40:4-10 |
| ISSN: | 1651-1980 0036-5548 |
| DOI: | 10.1080/00365540701522934 |
| Popis: | In 2002, two cases of tick-borne encephalitis (TBE) were diagnosed in inhabitants of a tick endemic area on the island of Aspö in south-east Sweden. During the previous 25 y, only 2 other cases of TBE had been diagnosed in that region of Sweden. To investigate the presence and evolution of seroprevalence of antibodies to TBE virus (TBEV), we compared inhabitants' anti-TBEV immunoglobulin G (IgG) levels in blood samples drawn in 1991 and 2002. A significant increase in IgG antibody levels was observed in 24/200 (12.0%) 2002 blood samples compared to 7/200 (3.5%) 1991 samples. However, neutralizing antibodies were detected in only 4 of the 2-step enzyme-linked immunosorbent assay (ELISA) IgG positive sera against TBEV, corresponding to a TBEV neutralizing test (NT) prevalence of 2%. Significantly more men than women were seropositive for TBEV antibodies. Compared to other age groups, the greatest increase in TBEV antibody levels was observed in the 20-29-y age group. However, the majority of seropositive samples were from participants50 y of age. Recommending preventative measures, including vaccination against TBE, to individuals who reside in or regularly visit TBEV endemic areas is suggested. |
| Databáze: | OpenAIRE |
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