Patient experience in a randomized trial of a weekly progesterone vaginal ring versus a daily progesterone gel for luteal support after in vitro fertilization
| Autor: | Gaurang S. Daftary, Teru Jellerette-Nolan, Elizabeth S. Ginsburg, Yunling Du, Kaylen M. Silverberg |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Randomization Adolescent Fertilization in Vitro Luteal Phase Luteal phase Drug Administration Schedule law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Patient satisfaction Randomized controlled trial Pregnancy law Surveys and Questionnaires Post-hoc analysis medicine Humans Single-Blind Method Prospective Studies Progesterone Luteal support 030219 obstetrics & reproductive medicine Obstetrics business.industry Contraceptive Devices Female Obstetrics and Gynecology Vaginal ring Clinical trial Administration Intravaginal 030104 developmental biology Reproductive Medicine Vaginal Creams Foams and Jellies Female Progestins business Infertility Female |
| Zdroj: | Fertility and Sterility. 110:1101-1108.e3 |
| ISSN: | 0015-0282 |
| Popis: | To assess patient experience and convenience of using progesterone vaginal ring (VR) versus vaginal gel for women requiring luteal phase support during in vitro fertilization (IVF).Post hoc analysis of a prospective, randomized, single-blind, multicenter, phase 3 clinical trial.Twenty-two U.S. IVF centers.Women undergoing IVF (N = 1,297).Randomization to weekly VR or daily gel the day after egg retrieval for up to 10 weeks, with fresh embryo transfer IVF per site-specific procedures.Patient satisfaction questionnaire completed at final study visit.In the women who were taking ≥1 dose of either VR (n = 647) or gel (n = 650),97% reported that learning to use the formulation, remembering to take it at the correct time, and using it as prescribed was "easy" or "somewhat easy." More VR than gel users reported noninterference with daily activity (93.3% vs. 74.7%, P.001), sexual comfort (80.3% vs. 67.8%, P.001), and sexual desire (73.8% vs. 61.8%, P.001), as well as not being bothered during sexual intercourse (66.9% vs. 39.2%, P.001). More gel than VR users reported no difficulty with application (97.4% vs. 80.9%, P.001). Among women who had previously used progesterone during IVF, more VR users than gel users preferred their currently assigned treatment to their previous treatment (91.4% vs. 83.0%, P=.03).Weekly progesterone VR and daily progesterone gel were easy to use, with limited impact on quality of life. Overall, the VR appeared to interfere less with daily life, social activities, and sexual activity although the gel was less difficult or stressful to apply.NCT00615251. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|