Dissecting the evolutionary role of the Hox gene proboscipedia in Drosophila mouthpart diversification by full locus replacement
| Autor: | Ankush Auradkar, William McGinnis, Sushil Devkota, Ethan Bier, Emily A Bulger |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Evolutionary Biology
Earth Environmental Ecological and Space Sciences Multidisciplinary biology Proboscis SciAdv r-articles Locus (genetics) biology.organism_classification Arthropod mouthparts Regulatory sequence Evolutionary biology Melanogaster Drosophila (subgenus) Drosophila melanogaster Hox gene Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abk1003 |
| Popis: | Description Full replacement of D. melanogaster pb Hox locus with D. mimica pb locus produces mouthparts with similarities to D. mimica. Hox genes determine positional codes along the head-to-tail axis. Here, we replaced the entire Drosophila melanogaster proboscipedia (pb) Hox locus, which controls the development of the proboscis and maxillary palps, with that from Drosophila mimica, a related species with highly modified mouthparts. The D. mimica replacement rescues most aspects of adult proboscis morphology; however, the shape and orientation of maxillary palps were modified, resembling D. mimica and closely related species. Expressing the D. mimica Pb protein in the D. melanogaster pattern fully rescued D. melanogaster morphology. However, the expression pattern directed by D. mimica pb cis-regulatory sequences differed from that of D. melanogaster pb in cells that produce altered maxillary structures, indicating that pb regulatory sequences can evolve in related species to alter morphology. |
| Databáze: | OpenAIRE |
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