Bronchodilator Responses to Salbutamol Using Diskhaler Versus Metered-Dose Inhaler
| Autor: | M, Kou, M, Phil, C R, Kumana, M S, Ip, I J, Lauder, W K, Lam, J C, Chan |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.drug_class Peak Expiratory Flow Rate Placebo Statistics Nonparametric Double-Blind Method Bronchodilator Humans Immunology and Allergy Medicine Albuterol Asthma Cross-Over Studies Dose-Response Relationship Drug Inhalation business.industry Nebulizers and Vaporizers Equipment Design Adrenergic beta-Agonists Middle Aged medicine.disease Crossover study Metered-dose inhaler Bronchodilator Agents Anesthesia Pediatrics Perinatology and Child Health Salbutamol Female business medicine.drug |
| Zdroj: | Journal of Asthma. 35:505-511 |
| ISSN: | 1532-4303 0277-0903 |
| DOI: | 10.3109/02770909809071004 |
| Popis: | In adults inhaling salbutamol via metered-dose inhalers (MDls) 200 microg doses are recommended, but with diskhalers the manufacturer advocates 400 rather than 200 microg doses. To assess this advice, a partially double-blind, placebo-controlled salbutamol dose response, crossover study (also incorporating MDI doses) was conducted in 12 mild/moderate asthmatics. After active treatment, mean peak expiratory flow rate (PEFR) increments yielded no clinically or statistically significant differences; compared to placebo, respective median differences in PEFR increments (95% Cls) were 10 (-10, 50), 20 (0, 50), and 15 (0, 30) following 400 and 200 microg via diskhalers and 200 microg via MDls. Diskhalers are a suitable alternative for patients with poor MDI technique, but the use of 400 rather than 200 microg salbutamol doses is not supported by evidence. |
| Databáze: | OpenAIRE |
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