Immunoregulatory Potential of Exosomes Derived from Cancer Stem Cells

Autor: Shyam Rao, Andrew C. Birkeland, Angela M. Beliveau, Joehleen A. Archard, Shannon M. Clayton, Marianne Abouyared, Peter C. Belafsky, Johnathon D. Anderson, Arnaud F. Bewley, Joseph Wagner, D. Gregory Farwell
Rok vydání: 2020
Předmět:
0301 basic medicine
cancer stem cells
Technology
Cell
Druggability
Exosomes
Medical and Health Sciences
0302 clinical medicine
Stem Cell Research - Nonembryonic - Human
Tumor Microenvironment
2.1 Biological and endogenous factors
Aetiology
Cell Self Renewal
secretory proteins
Cancer
Concise Review
Cell Differentiation
Hematology
regulatory T lymphocytes
Biological Sciences
Immunosurveillance
medicine.anatomical_structure
Local
Head and Neck Neoplasms
Carcinoma
Squamous Cell
Neoplastic Stem Cells
Stem Cell Research - Nonembryonic - Non-Human
Signal Transduction
Immunology
exosomes
Biology
Exosome
03 medical and health sciences
Rare Diseases
Cancer stem cell
Clinical Research
medicine
Humans
Dental/Oral and Craniofacial Disease
Mixed tumor
Mechanism (biology)
Carcinoma
Cell Biology
medicine.disease
Stem Cell Research
Microvesicles
m2 macrophages
030104 developmental biology
Neoplasm Recurrence
Squamous Cell
Cancer research
head and neck cancer
Neoplasm Recurrence
Local
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Stem cells and development, vol 29, iss 6
Stem Cells Dev
Popis: Head and neck squamous cell carcinomas (HNSCCs) are malignancies that originate in the mucosal lining of the upper aerodigestive tract. Despite advances in therapeutic interventions, survival rates among HNSCC patients have remained static for years. Cancer stem cells (CSCs) are tumor-initiating cells that are highly resistant to treatment, and are hypothesized to contribute to a significant fraction of tumor recurrences. Consequently, further investigations of how CSCs mediate recurrence may provide insights into novel druggable targets. A key element of recurrence involves the tumor's ability to evade immunosurveillance. Recent published reports suggest that CSCs possess immunosuppressive properties, however, the underlying mechanism have yet to be fully elucidated. To date, most groups have focused on the role of CSC-derived secretory proteins, such as cytokines and growth factors. Here, we review the established immunoregulatory role of exosomes derived from mixed tumor cell populations, and propose further study of CSC-derived exosomes may be warranted. Such studies may yield novel insights into new druggable targets, or lay the foundation for future exosome-based diagnostics.
Databáze: OpenAIRE
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