Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches
| Autor: | Sajib Rudra, Md. Masudur Rahman Mamun, Nahid Akhter, Nazim Uddin Emon, Md. Munsur Alam, Amlan Ganguly, Safaet Alam |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Diarrhea Antipyretics Fever In silico Analgesic Anti-Inflammatory Agents Pain Ibuprofen RM1-950 Albendazole Tubifex tubifex Loperamide 03 medical and health sciences Feces Mice 0302 clinical medicine Lygodium microphyllum In vivo medicine Animals Anthelmintic Antipyretic Antidiarrheals ADME Pharmacology Anthelmintics Inflammation Analgesics biology Traditional medicine COX-1 Plant Extracts General Medicine COX-2 biology.organism_classification Molecular Docking Simulation Plant Leaves 030104 developmental biology 030220 oncology & carcinogenesis Molecular docking Ferns Therapeutics. Pharmacology Fern Pyrexia medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111644-(2021) |
| ISSN: | 1950-6007 |
| Popis: | Lygodium microphyllum Cav. (Family: Lygodiaceae) is a perennial, snake fern and an invasive weed in Florida and also known as old world climbing fern. This study is intended to evaluate the antipyretic, analgesic, anti-inflammatory, antidiarrheal and anthelmintic activity of methanol extract of Lygodium microphyllum Cav. leaves (MELM) by in vivo, in vitro and in silico approaches. In addition, Biovia, PyRx autoDock Vina, UCSF Chimera have been applied to investigate the docking study in order to evaluate the binding interaction and an online tool was used to explore the ADME/T properties of selected bioactive compounds. In acetic acid induced writhing study, MELM inhibited 44.28% and 56.61% of writhes at 200 and 400 (mg/kg) respectively compared to standard drug Diclofenac-Na (10 mg/kg) (74.42% inhibition). In anti-inflammatory experiment by formalin triggered licking method, MELM caused significant (p |
| Databáze: | OpenAIRE |
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