Drug Adherence in Patients With Nonvalvular Atrial Fibrillation Taking Non-Vitamin K Antagonist Oral Anticoagulants in Turkey: NOAC-TR
| Autor: | Çağrı Yayla, Baris Celebi, Onur Dalgıç, Ismail Bolat, Özgen Şafak, Abdullah Aslan, Hakan Çakir, Gonul Aciksari, Serdar Akyel, Mehdi Zoghi, Barış Düzel, Osman Beton, Lütfü Bekar, Oktay Şenöz, Murat Bilgin, Sadık Volkan Emren, Oğuzhan Çelik, Lale Dinc Asarcikli, Hasan Güngör, Ugur Taskin |
|---|---|
| Přispěvatelé: | Ege Üniversitesi, [Emren, Sadik Volkan] Afyonkarahisar State Hosp, Dept Cardiol, TR-03000 Afyon, Turkey -- [Senoz, Oktay] Artvin State Hosp, Dept Cardiol, Artvin, Turkey -- [Bilgin, Murat -- Asarcikli, Lale Dinc] Ankara Diskapi Res & Educ Hosp, Dept Cardiol, Ankara, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Dept Cardiol, Sivas, Turkey -- [Aslan, Abdullah] Dokuz Eylul Univ, Dept Cardiol, Izmir, Turkey -- [Taskin, Ugur] Aksehir State Hosp, Dept Cardiol, Konya, Turkey -- [Aciksari, Gonul] Istanbul Istinye State Hosp, Dept Cardiol, Istanbul, Turkey -- [Cakir, Hakan] Darica Farabi State Hosp, Dept Cardiol, Kocaeli, Turkey -- [Bekar, Lutfu] Hitit Univ, Dept Cardiol, Corum, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Mugla, Turkey -- [Yayla, Cagri] Ankara Yuksek Ihtisas Res & Educ Hosp, Dept Cardiol, Ankara, Turkey -- [Celebi, Baris] Silifke State Hosp, Dept Cardiol, Mersin, Turkey -- [Dalgic, Onur] Karsiyaka State Hosp, Dept Cardiol, Izmir, Turkey -- [Celik, Oguzhan] Hitit Univ, Sch Med, Dept Cardiol, Corum, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Akyel, Serdar] Munif Islamoglu State Hosp, Dept Cardiol, Kastamonu, Turkey -- [Gungor, Hasan] Aydin Univ, Sch Med, Dept Cardiol, Aydin, Turkey -- [Duzel, Baris] Mersin State Hosp, Dept Cardiol, Mersin, Turkey -- [Zoghi, Mehdi] Ege Univ, Dept Cardiol, Izmir, Turkey, Hitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Turkish population Turkey medicine.drug_class Hemorrhage 030204 cardiovascular system & hematology Dabigatran 03 medical and health sciences 0302 clinical medicine Internal medicine Atrial Fibrillation medicine Humans 030212 general & internal medicine Stroke non-vitamin K antagonists Depression (differential diagnoses) Aged Aged 80 and over Rivaroxaban business.industry Anticoagulants Atrial fibrillation Hematology General Medicine Original Articles Vitamin K antagonist Middle Aged self-report medicine.disease bleeding Cross-Sectional Studies medication adherence Cardiology Apixaban Female Self Report business medicine.drug |
| Popis: | WOS: 000429775000020 PubMed ID: 28301907 Adherence to non-vitamin K antagonist oral anticoagulants (NOACs) is an important factor for ensuring efficacy and safety in nonvalvular atrial fibrillation (NVAF). There are controversial results regarding NOAC adherence in real-world data and there are no data about NOAC adherence in Turkish population. This study investigated the NOAC adherence based on self-report, factors affecting nonadherence, and the relation of the adherence level with efficacy and safety outcomes. This multicenter cross-sectional study included 2738 patients (59% female) using NOAC (dabigatran, apixaban, and rivaroxaban) due to NVAF for more than 3 months with >30 days of supply between September 1, 2015, and February 28, 2016. To measure the adherence level, an 8-item Morisky Medication Adherence Scale was used. The mean age of the patients was 70 +/- 10 years. Of the 2738 patients, 44% were receiving dabigatran, 38% rivaroxaban, and 18% apixaban. A total of 630 (23%) patients had high medication adherence, 712 (26%) moderate adherence, and 1396 (51%) low adherence. Nonadherence had related to stroke (5.6% vs 2.5%, P < .001) and minor (21.2% vs 11.1%, P < .001) and major (6.1% vs 3.7%, P = .004) bleeding rates. The adherence to NOAC was found to be quite low in Turkey. Nonadherence is associated with bleeding and thromboembolic cardiovascular events. Age, taking NOAC twice a day, and the additional noncardiac diseases, depression, and dementia were the independent factors affecting poor medication adherence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|