Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status
| Autor: | Tae Min Jung, Young H. Sohn, Seung Koo Lee, Ji E. Lee, Seo Hee Choi, Phil Hyu Lee |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Aging medicine.medical_specialty Parkinson's disease Substantia Innominata Internal medicine medicine Humans Dementia Cognitive Dysfunction Prospective Studies Effects of sleep deprivation on cognitive performance Prospective cohort study Aged Basal forebrain medicine.diagnostic_test General Neuroscience Substantia innominata Parkinson Disease Cognition Magnetic resonance imaging Organ Size Middle Aged medicine.disease Magnetic Resonance Imaging Cardiology Female Neurology (clinical) Geriatrics and Gerontology Cognition Disorders Psychology Neuroscience Developmental Biology |
| Zdroj: | Neurobiology of Aging. 33:1265-1272 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2010.11.015 |
| Popis: | The cholinergic system arising from the substantia innominata (SI) of the basal forebrain has an important role in the cognitive functions of Parkinson's disease (PD). We performed magnetic resonance imaging based volumetric analysis to evaluate the SI volume in patients with PD-intact cognition (PD-IC), PD-mild cognitive impairment (PD-MCI), and PD dementia (PDD). The mean normalized SI volume was significantly decreased in patients with PD-IC (1.54 ± 0.12, p < 0.001), PD-MCI (1.49 ± 0.12, p < 0.001), and PDD (1.39 ± 0.12, p < 0.001) compared with that of control subjects (1.68 ± 0.11). The normalized SI volume did not differ between patients with PD-IC and PD-MCI; however, the normalized SI volume was significantly decreased in patients with PDD compared with that in those with PD-IC (p < 0.001) or PD-MCI (p = 0.016). The normalized SI volume was significantly correlated with general cognitive status (r = 0.51, p < 0.001) as well as with performance in each cognitive subdomain, with a particularly significant independent association with attention (β = 0.33, p = 0.003) and object naming (β = 0.26, p = 0.017). The present study demonstrated that the SI volume in PD differs depending on cognitive status and is significantly correlated with cognitive performance. |
| Databáze: | OpenAIRE |
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