Infectious agents in immunodeficient murine models: pathogenicity of Actinomyces israelii serotype I in congenitally athymic (nude) mice
| Autor: | S Maslan, Blaine L. Beaman, M E Gershwin |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Serotype
Pathology medicine.medical_specialty T-Lymphocytes Immunology Mice Nude Actinomycosis Microbiology Serology Mice medicine Actinomyces Animals Serotyping Lung biology Lethal dose biology.organism_classification medicine.disease Actinomyces israelii Immunity Innate Infectious Diseases medicine.anatomical_structure Face Parasitology Nasal administration Neck Research Article |
| Zdroj: | Infection and Immunity. 24:583-585 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.24.2.583-585.1979 |
| Popis: | Nude (Nu/Nu) and heterozygous (NU/+) mice were infected with Actinomyces israelii serotype I by either intranasal instillation or intravenous injection. Lung clearance data and 50% lethal dose values indicated that T-lymphocytes were not necessary for pulmonary clearance or prevention of systemic actinomycosis. However, T-lymphocyte deficiency may play a role in the localized cervicofacial form of actinomycosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|