Responses to booster hepatitis B vaccination are significantly correlated with genotypes of human leukocyte antigen (HLA)-DPB1 in neonatally vaccinated adolescents
| Autor: | Tzu-Wei Wu, Huei-Wen Chang Liao, Marie Lin, Tzu-Ying Ho, Sheng-Kai Lin, Chen-Chung Chu, Li-Yu Wang, Hans Hsienhong Lin |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Adolescent Genotype Immunization Secondary Human leukocyte antigen Biology medicine.disease_cause Antigen Gene Frequency Risk Factors Genetics medicine Odds Ratio Humans Hepatitis B Vaccines Hepatitis B Antibodies Genetics (clinical) HLA-DP beta-Chains Hepatitis B virus HLA-DPB1 Vaccination Case-control study Hepatitis B medicine.disease Genetic Loci Case-Control Studies Immunology Female |
| Zdroj: | Human genetics. 132(10) |
| ISSN: | 1432-1203 |
| Popis: | Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the human leukocyte antigen (HLA)-DP loci that were significantly correlated with outcomes of hepatitis B virus (HBV) infection. We performed a case–control study nested in a well-characterized cohort of booster recipients to assess whether genetic variants of HLA-DPB1 are also associated with response to hepatitis B (HB) vaccination. The cases and controls were 171 and 510 booster recipients whose post-booster titers of antibodies against HBV surface antigen (anti-HBs) were undetectable and detectable, respectively. The HLA-DPB1 genotype was determined using sequence-based techniques. The frequencies of HLA-DPB1 alleles were significantly different between cases and controls (p = 1.7 × 10−8). The HLA-DPB1 05:01 and 09:01 alleles were significantly more frequent in the cases, and 02:01:02, 02:02, 03:01:01, 04:01:01, and 14:01, were significantly more frequent in the controls. The adjusted odds ratio (OR) of undetectable post-booster anti-HBs titers was significantly correlated with the number of risk alleles (p for trend = 3.8 × 10−5). For the number of protective alleles, the trend was significantly inversed (p for trend = 1.3 × 10−5). As compared with subjects with two risk alleles, adjusted OR were 0.34 (95 % confidence interval [CI] 0.21–0.55) and 0.20 (95 % CI 0.08–0.48) for subjects with 1 and 2 protective alleles, respectively. The HLA-DPB1 02:02, 04:01:01, 05:01 and 09:01 alleles were also significantly correlated with the likelihoods of undetectable pre-booster anti-HBs titers. Our results indicated that HLA-DPB1 is significantly correlated with response to booster HB vaccination in adolescent who had received postnatal active HB vaccination. HLA-DBP1 may also determine the long-term persistence of response to HB vaccination. |
| Databáze: | OpenAIRE |
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