Adding historical high-sensitivity troponin T results to rule out acute myocardial infarction

Autor:	Andreas Roos, Moman A Mohammad, Ulf Ekelund, Arash Mokhtari, Martin J Holzmann
Rok vydání:	2022
Předmět:	Chest Pain Troponin T Predictive Value of Tests Myocardial Infarction Humans General Medicine Emergency Service Hospital Cardiology and Cardiovascular Medicine Critical Care and Intensive Care Medicine Biomarkers
Zdroj:	European Heart Journal. Acute Cardiovascular Care. 11:215-223
ISSN:	2048-8734 2048-8726
Popis:	Aims The clinical usefulness of historical concentrations of high-sensitivity cardiac troponin T (hs-cTnT) is unknown. This study investigated the ability to rule out myocardial infarction (MI) with the use of historical hs-cTnT concentrations among patients with chest pain in the emergency department (ED). Methods and results The derivation cohort consisted of patients presenting with chest pain to nine different EDs (n = 60 071), where we included those with ≥1 hs-cTnT analysed at the index visit and ≥1 hs-cTnT results prior to the visit. We developed an algorithm to rule out MI within 30 days with a pre-specified target negative predictive value (NPV) of ≥99.5%. The performance was then validated in a separate cohort of ED chest pain patients (n = 10 994). A historical hs-cTnT Conclusion Combining a historical hs-cTnT with a single new hs-cTnT may safely rule out MI and thereby reduce the need for serial hs-cTnT measurements in ED patients with chest pain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f770ba77780735cad9a68cdbe527cd3 https://doi.org/10.1093/ehjacc/zuab123 Zobrazit plný text záznamu