Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents
| Autor: | Yong-Kun Li, Ze-Wei Mao, Xiaobi Yang, Hui Gao, Minxin Li, Yanling Tang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Chalcone
Staphylococcus aureus Sulfonamides biology Organic Chemistry Bacillus subtilis Microbial Sensitivity Tests biology.organism_classification medicine.disease_cause Biochemistry Combinatorial chemistry In vitro Piperazines Anti-Bacterial Agents chemistry.chemical_compound Piperazine Chalcones chemistry Mic values medicine Escherichia coli Antibacterial activity |
| Zdroj: | Current organic synthesis. 17(2) |
| ISSN: | 1570-1794 |
| Popis: | Background: Infection is a global threat to human health, and there is an urgent need to develop new effective antibacterial drugs to treat bacterial infections. Objective: To study the antibacterial activity of piperazine substituted chalcone sulphonamides. Materials and Methods: A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated. Results: The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against Bacillus subtilis with MIC values of 4.0-8.0 mg/mL. Conclusion: Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents. |
| Databáze: | OpenAIRE |
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