Estimates of urinary blood lead clearance and its relationship to glomerular filtration rate based on a large population survey
| Autor: | James S. Brown, Mark H. Follansbee, Linda G. T. Gaines, Gary Diamond, William C. Thayer, Julie M Klotzbach, Michele Burgess |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Health Toxicology and Mutagenesis Urinary system 030232 urology & nephrology Large population Urology Renal function Urine 010501 environmental sciences urologic and male genital diseases Toxicology 01 natural sciences Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood serum medicine Humans Lead (electronics) Aged 0105 earth and related environmental sciences Aged 80 and over Creatinine urogenital system business.industry Middle Aged United States female genital diseases and pregnancy complications Lead chemistry Blood chemistry Female business Glomerular Filtration Rate |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A. 82:379-382 |
| ISSN: | 1087-2620 1528-7394 2009-2016 |
| Popis: | Blood lead (Pb) clearance (CbPb) and serum creatinine clearance (CsCr), a metric of glomerular filtration rate (GFR), were estimated in approximately 7,600 subjects from the NHANES (2009-2016). Median CbPb in adults was 0.04 L/day (5th-95th percentile range: 0.01-0.12). Linear regression models explained approximately 68% of variance in CbPb in adults, with98% of explained variance attributed to CsCr. These results provide an improved quantitative understanding of the possible effects of reverse causality in the interpretation of studies of associations between blood Pb and decrements in GFR. |
| Databáze: | OpenAIRE |
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