Lack of benefit of concurrent chemotherapy in patients with cervical cancer and negative lymph nodes by FDG-PET
| Autor: | Farrokh Dehdashti, Perry W. Grigsby, David G. Mutch, Imran Zoberi, Thomas J. Herzog, Janet S. Rader, Barry A. Siegel |
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| Rok vydání: | 2003 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Radiation-Sensitizing Agents medicine.medical_treatment Uterine Cervical Neoplasms Antineoplastic Agents Adenocarcinoma Fluorodeoxyglucose F18 Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Registries Pelvis Proportional Hazards Models Cervical cancer Cisplatin Chemotherapy Radiation Proportional hazards model business.industry Colostomy Middle Aged medicine.disease Combined Modality Therapy Survival Analysis medicine.anatomical_structure Rectovaginal fistula Lymphatic Metastasis Carcinoma Squamous Cell Female Lymph Radiopharmaceuticals business medicine.drug Tomography Emission-Computed |
| Zdroj: | International journal of radiation oncology, biology, physics. 61(2) |
| ISSN: | 0360-3016 |
| Popis: | Purpose To compare the outcome of patients with cervical cancer and negative lymph nodes by fluorodeoxyglucose-positron emission tomography (FDG-PET) treated with irradiation (RT) and concurrent chemotherapy or RT alone. Methods and materials This was a prospective data registry of 65 patients with cervical cancer and negative lymph nodes by whole-body FDG-PET. The tumor stage was IB2 in 11, IIB in 37, and IIIB in 17 patients. RT alone was administered to 15 and RT with concurrent weekly cisplatin to 50 patients. Results The 5-year overall survival estimate was 85% with RT and 81% with RT and concurrent chemotherapy ( p = 0.91). The corresponding 5-year cause-specific survival estimates were 78% and 74% ( p = 0.98). The differences in the sites of recurrence (pelvis vs. distant metastasis) were not statistically significant between the two groups ( p = 0.77). A Cox proportional hazards model of survival outcome did not identify chemotherapy, overall treatment time, or radiation dose as statistically significant prognostic factors. Severe complications included one rectovaginal fistula, one rectal stricture requiring colostomy (both in the concurrent chemotherapy group), and one death from chemotherapy-related complications. Conclusion Irradiation with concurrent cisplatin was not advantageous compared with RT alone in patients with negative lymph nodes on FDG-PET. |
| Databáze: | OpenAIRE |
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