Chronic metabolic alkalosis, sucrose diet and dentine formation in young rats
| Autor: | Markku Larmas, T. Bäckman |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Molar
Male medicine.medical_specialty Sucrose Alkalosis Partial Pressure Metabolic alkalosis Dentistry Mandibular second molar chemistry.chemical_compound stomatognathic system Dietary Sucrose Internal medicine Medicine Animals Rats Wistar General Dentistry Analysis of Variance business.industry Cell Biology General Medicine Carbon Dioxide Dentinogenesis Hydrogen-Ion Concentration medicine.disease Rats Oxygen Apposition Endocrinology Sodium Bicarbonate Otorhinolaryngology chemistry Distilled water Female business |
| Zdroj: | Archives of oral biology. 42(4) |
| ISSN: | 0003-9969 |
| Popis: | As acid-base status has an effect on bone formation and remodelling, chronic metabolic alkalosis was induced in 3-week-old rats for 6 and 7 weeks with 0.25 mol/l of NaHC0 3 in their drinking water to determine whether it has any effect on dentinogenesis in the molars. One group of rats was fed a high-sucrose diet and the other two a standard diet. The control groups had the same diets but drank distilled water. All the rats were injected with tetracycline to mark the onset of dentine apposition. The alkalosic effect of the NaHC0 3 drinking water was confirmed by blood gas analysis at the end of the experiment. After death, tetracycline-marked dentine apposition was measured from sagittally sectioned mandibular molars. Chronic metabolic alkalosis did not affect dentine apposition in the groups with the high-sucrose diet, nor in the groups with the standard diet at 6 weeks, but reduced it significantly in first and second molars in 7 weeks at rats on the standard diet. A high-sucrose diet alone caused a greater reduction in the amount of dentine. The general growth of the rats was riot affected in any of the groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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