White matter hyperintensity volume in pre-diabetes, diabetes and normoglycemia

Autor: Susanne Rospleszcz, Felix Hartmann, Sophia Stoecklein, Karl-Heinz Ladwig, Birgit Ertl-Wagner, Sigrid Auweter, Sergio Grosu, Sonja Selder, Wolfgang Rathmann, Franziska Galiè, Christopher L. Schlett, Annette Peters, Margit Heier, Roberto Lorbeer, Katharina Mueller-Peltzer, Fabian Bamberg
Rok vydání: 2020
Předmět:
Male
pre-diabetic state
medicine.medical_specialty
Cardiovascular and Metabolic Risk
brain diseases
Endocrinology
Diabetes and Metabolism
Population
Mri
Brain Diseases
Diabetes Complications
Metabolic
Pre-diabetic State
030204 cardiovascular system & hematology
Diseases of the endocrine glands. Clinical endocrinology
Prediabetic State
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
metabolic
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Cognitive Dysfunction
ddc:610
Risk factor
Cognitive decline
education
Stroke
Glycemic
Aged
education.field_of_study
business.industry
diabetes complications
Middle Aged
RC648-665
medicine.disease
Magnetic Resonance Imaging
White Matter
Hyperintensity
ddc
chemistry
Female
Glycated hemoglobin
business
030217 neurology & neurosurgery
MRI
Zdroj: BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
BMJ Open Diab. Res. Care 9:e002050 (2021)
ISSN: 2052-4897
Popis: IntroductionAs white matter hyperintensities (WMHs) of the brain are associated with an increased risk of stroke, cognitive decline, and depression, elucidating the associated risk factors is important. In addition to age and hypertension, pre-diabetes and diabetes may play important roles in the development of WMHs. Previous studies have, however, shown conflicting results. We aimed to investigate the effect of diabetes status and quantitative markers of glucose metabolism on WMH volume in a population-based cohort without prior cardiovascular disease.Research design and methods400 participants underwent 3 T MRI. WMHs were manually segmented on 3D fluid-attenuated inversion recovery images. An oral glucose tolerance test (OGTT) was administered to all participants not previously diagnosed with diabetes to assess 2-hour serum glucose concentrations. Fasting glucose concentrations and glycated hemoglobin (HbA1c) levels were measured. Zero-inflated negative binomial regression analyses of WMH volume and measures of glycemic status were performed while controlling for cardiovascular risk factors and multiple testing.ResultsThe final study population comprised 388 participants (57% male; age 56.3±9.2 years; n=98 with pre-diabetes, n=51 with diabetes). Higher WMH volume was associated with pre-diabetes (p=0.001) and diabetes (p=0.026) compared with normoglycemic control participants after adjustment for cardiovascular risk factors. 2-hour serum glucose (pConclusionOur results indicate that high 2-hour serum glucose concentration in OGTT, but not fasting glucose levels, may be an independent risk factor for the development of WMHs, with the potential to inform intensified prevention strategies in individuals at risk of WMH-associated morbidity.
Databáze: OpenAIRE
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