White matter hyperintensity volume in pre-diabetes, diabetes and normoglycemia
Autor: | Susanne Rospleszcz, Felix Hartmann, Sophia Stoecklein, Karl-Heinz Ladwig, Birgit Ertl-Wagner, Sigrid Auweter, Sergio Grosu, Sonja Selder, Wolfgang Rathmann, Franziska Galiè, Christopher L. Schlett, Annette Peters, Margit Heier, Roberto Lorbeer, Katharina Mueller-Peltzer, Fabian Bamberg |
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Rok vydání: | 2020 |
Předmět: |
Male
pre-diabetic state medicine.medical_specialty Cardiovascular and Metabolic Risk brain diseases Endocrinology Diabetes and Metabolism Population Mri Brain Diseases Diabetes Complications Metabolic Pre-diabetic State 030204 cardiovascular system & hematology Diseases of the endocrine glands. Clinical endocrinology Prediabetic State 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine metabolic Internal medicine Diabetes mellitus medicine Diabetes Mellitus Humans Cognitive Dysfunction ddc:610 Risk factor Cognitive decline education Stroke Glycemic Aged education.field_of_study business.industry diabetes complications Middle Aged RC648-665 medicine.disease Magnetic Resonance Imaging White Matter Hyperintensity ddc chemistry Female Glycated hemoglobin business 030217 neurology & neurosurgery MRI |
Zdroj: | BMJ Open Diabetes Research & Care BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021) BMJ Open Diab. Res. Care 9:e002050 (2021) |
ISSN: | 2052-4897 |
Popis: | IntroductionAs white matter hyperintensities (WMHs) of the brain are associated with an increased risk of stroke, cognitive decline, and depression, elucidating the associated risk factors is important. In addition to age and hypertension, pre-diabetes and diabetes may play important roles in the development of WMHs. Previous studies have, however, shown conflicting results. We aimed to investigate the effect of diabetes status and quantitative markers of glucose metabolism on WMH volume in a population-based cohort without prior cardiovascular disease.Research design and methods400 participants underwent 3 T MRI. WMHs were manually segmented on 3D fluid-attenuated inversion recovery images. An oral glucose tolerance test (OGTT) was administered to all participants not previously diagnosed with diabetes to assess 2-hour serum glucose concentrations. Fasting glucose concentrations and glycated hemoglobin (HbA1c) levels were measured. Zero-inflated negative binomial regression analyses of WMH volume and measures of glycemic status were performed while controlling for cardiovascular risk factors and multiple testing.ResultsThe final study population comprised 388 participants (57% male; age 56.3±9.2 years; n=98 with pre-diabetes, n=51 with diabetes). Higher WMH volume was associated with pre-diabetes (p=0.001) and diabetes (p=0.026) compared with normoglycemic control participants after adjustment for cardiovascular risk factors. 2-hour serum glucose (pConclusionOur results indicate that high 2-hour serum glucose concentration in OGTT, but not fasting glucose levels, may be an independent risk factor for the development of WMHs, with the potential to inform intensified prevention strategies in individuals at risk of WMH-associated morbidity. |
Databáze: | OpenAIRE |
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