Reciprocal regulation of cellular mechanics and metabolism
| Autor: | Alireza Mashaghi, Tom M J Evers, Liam J. Holt, Simon Alberti |
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| Rok vydání: | 2021 |
| Předmět: |
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Extramural Endocrinology Diabetes and Metabolism Cell Cell Biology Metabolism Cellular mechanics Biology Mechanotransduction Cellular Article medicine.anatomical_structure Physiology (medical) Organelle Internal Medicine medicine Animals Humans Stress Mechanical Cytoskeleton Signalling pathways Neuroscience Signal Transduction |
| Zdroj: | Nat Metab |
| ISSN: | 2522-5812 |
| DOI: | 10.1038/s42255-021-00384-w |
| Popis: | Metabolism and mechanics are intrinsically intertwined. External forces, sensed through the cytoskeleton or distortion of the cell and organelles, induce metabolic changes in the cell. The resulting changes in metabolism, in turn, feed back to regulate every level of cell biology, including the mechanical properties of cells and tissues. Here we examine the links between metabolism and mechanics, highlighting signalling pathways involved in the regulation and response to cellular mechanosensing. We consider how forces and metabolism regulate one another through nanoscale molecular sensors, micrometre-scale cytoskeletal networks, organelles and dynamic biomolecular condensates. Understanding this cross-talk will create diagnostic and therapeutic opportunities for metabolic disorders such as cancer, cardiovascular pathologies and obesity. |
| Databáze: | OpenAIRE |
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