Mortality in patients with psoriasis. A retrospective cohort study
| Autor: | Walter Masson, Arturo Cagide, José Luis Navarro Estrada, Ricardo Galimberti, Juan Krauss, María Laura Galimberti, Emiliano Rossi |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Population Argentina Disease 030204 cardiovascular system & hematology Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Psoriasis Prevalence medicine Humans In patient education Survival analysis Aged Retrospective Studies Aged 80 and over education.field_of_study business.industry Mortality rate Electronic medical record Retrospective cohort study Middle Aged medicine.disease Surgery Cardiovascular Diseases Case-Control Studies Female business Follow-Up Studies |
| Zdroj: | Medicina Clínica (English Edition). 148:483-488 |
| ISSN: | 2387-0206 |
| Popis: | The immune and inflammatory pathways involved in psoriasis could favor the development of atherosclerosis, consequently increasing mortality. The objectives of this study were: 1) to assess the mortality of a population with psoriasis compared to a control group, and 2) to assess the prevalence of cardiovascular risk factors.A retrospective cohort was analyzed from a secondary database (electronic medical record). All patients with a diagnosis of psoriasis at 1-01-2010 were included in the study and compared to a control group of the same health system, selected randomly (1:1). Subjects with a history of cardiovascular disease were excluded from the study. A survival analysis was performed considering death from any cause as an event. Follow-up was extended until 30-06-2015.We included 1,481 subjects with psoriasis and 1,500 controls. Prevalence of cardiovascular risk factors was higher in the group with psoriasis. The average follow-up time was 4.6±1.7 years. Mortality was higher in psoriasis patients compared to controls (15.1 vs. 9.6 events per 1,000 person-year, P.005). Psoriasis was seen to be significantly associated with increased mortality rates compared to the control group in the univariate analysis (HR 1.58, 95% CI 1.16-2.15, P=.004) and after adjusting for cardiovascular risk factors (HR 1.48, 95% CI 1.08-2.3, P=.014).In this population, patients with psoriasis showed a higher prevalence for the onset of cardiovascular risk factors as well as higher mortality rates during follow-up. |
| Databáze: | OpenAIRE |
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