Impact of Obesity on Quality of Life, Psychological Distress, and Coping on Patients with Colon Cancer
| Autor: | Maria Valero Arbizu, Ruth Martínez Cabañes, David Gomez, Aránzazu Manzano Fernández, Estrella Ferreira, David Lorente Estellés, Alberto Carmona-Bayonas, Jorge Del Rio, Patricia Cruz Castellanos, Caterina Calderon, Paula Jiménez-Fonseca, T. García |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Colorectal cancer Psychological Distress Body Mass Index 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine Adaptation Psychological medicine Humans Obesity Prospective Studies Depression (differential diagnoses) 030304 developmental biology 0303 health sciences business.industry Cancer medicine.disease Oncology Symptom Management and Supportive Care 030220 oncology & carcinogenesis Cohort Colonic Neoplasms Quality of Life Neoplasm Recurrence Local business Psychosocial Body mass index |
| Zdroj: | Oncologist |
| Popis: | Background Despite the causal relationship between obesity and colon cancer being firmly established, the effect of obesity on the course of cancer calls for further elucidation. The objective of this study was to assess differences in clinical-pathological and psychosocial variables between obese and nonobese individuals with colon cancer. Materials and Methods This was a prospective, multicentric, observational study conducted from 2015–2018. The sample comprised patients with stage II–III, resected colon cancer about to initiate adjuvant chemotherapy with fluoropyrimidine in monotherapy or associated with oxaliplatin and grouped into nonobese (body mass index Results Seventy-nine of the 402 individuals recruited (19.7%) were obese. Obese subjects exhibited more comorbidities (≥2 comorbidities, 46.8% vs. 30.3%, p = .001) and expressed feeling slightly more postoperative pain (small size-effect). There was more depression, greater helplessness, less perceived social support from friends, and greater extraversion among the obese versus nonobese subjects (all p < .04). The nonobese group treated with fluoropyrimidine and oxaliplatin suffered more grade 3–4 hematological toxicity (p = .035), whereas the obese had higher rates of treatment withdrawal (17.7% vs. 7.7%, p = .033) and more recurrences (10.1% vs. 3.7%, p = .025). No differences in sociodemographic, quality of life, or 12-month survival variables were detected. Conclusion Obesity appears to affect how people confront cancer, as well as their tolerance to oncological treatment and relapse. Implications for Practice Obesity is a causal factor and affects prognosis in colorectal cancer. Obese patients displayed more comorbidities, more pain after cancer surgery, worse coping, and more depression and perceived less social support than nonobese patients. Severe hematological toxicity was more frequent among nonobese patients, whereas rates of withdrawal from adjuvant chemotherapy were higher in the obese cohort, and during follow-up, obese patients presented greater 12-month recurrence rates. With the growing and maintained increase of obesity and the cancers associated with it, including colorectal cancer, the approach to these more fragile cases that have a worse prognosis must be adapted to improve outcomes. |
| Databáze: | OpenAIRE |
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