Chronothyroidology: Chronobiological aspects in thyroid function and diseases
| Autor: | Antonio Bellastella, Silvia Mercadante, Lorenzo Scappaticcio, Annamaria De Bellis, Katherine Esposito, Giuseppe Bellastella, Maria Ida Maiorino |
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| Přispěvatelé: | Bellastella, G., Maiorino, M. I., Scappaticcio, L., De Bellis, A., Mercadante, S., Esposito, K., Bellastella, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Science 030209 endocrinology & metabolism Review Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Rhythm medicine Circadian rhythm Ecology Evolution Behavior and Systematics Ultradian rhythm Chronobiology Biological rhythm Suprachiasmatic nucleus Thyroid Paleontology Rhythm disruption Thyroid diseases biological rhythms 030104 developmental biology medicine.anatomical_structure Space and Planetary Science Thyroid function Neuroscience Hormone |
| Zdroj: | Life, Vol 11, Iss 426, p 426 (2021) Life |
| Popis: | Chronobiology is the scientific discipline which considers biological phenomena in relation to time, which assumes itself biological identity. Many physiological processes are cyclically regulated by intrinsic clocks and many pathological events show a circadian time-related occurrence. Even the pituitary–thyroid axis is under the control of a central clock, and the hormones of the pituitary–thyroid axis exhibit circadian, ultradian and circannual rhythmicity. This review, after describing briefly the essential principles of chronobiology, will be focused on the results of personal experiences and of other studies on this issue, paying particular attention to those regarding the thyroid implications, appearing in the literature as reviews, metanalyses, original and observational studies until 28 February 2021 and acquired from two databases (Scopus and PubMed). The first input to biological rhythms is given by a central clock located in the suprachiasmatic nucleus (SCN), which dictates the timing from its hypothalamic site to satellite clocks that contribute in a hierarchical way to regulate the physiological rhythmicity. Disruption of the rhythmic organization can favor the onset of important disorders, including thyroid diseases. Several studies on the interrelationship between thyroid function and circadian rhythmicity demonstrated that thyroid dysfunctions may affect negatively circadian organization, disrupting TSH rhythm. Conversely, alterations of clock machinery may cause important perturbations at the cellular level, which may favor thyroid dysfunctions and also cancer. |
| Databáze: | OpenAIRE |
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