| Popis: |
The article is devoted to the analysis of one of the main safety requirements of new products in the food industry, and biologically active substances - the definition of subchronic toxicity. Harmful effects after the additional introduction of the substance under research during a certain period of life of experimental animals are identified in order to determine its effect on the human body for approximately one month of its daily consumption. The subchronic toxicity of the combined agents was assessed in comparison with the reference test sample. Objects of study: 1) ZRHCH - film-forming composition on the basis of chіtosan and extracts of aloe leaves, chamomile bloom and bark of a fi- tree; 2) ZRHV - film-forming composition on the basis of chіtosan and extracts of eucalyptus leaves and grass of basil and thyme; 3) ZRHA - film-forming composition on the basis of chіtosan and extracts of leaves of balm, leaves of salvia and verbena grass. 4) PTZY is the reference composition composed of iodine, calcium iodide, citric acid, amylodextrin, sulfonol, purified water is a solvent. With proper planning of a subchronic study, it is possible to obtain valuable information about the cumulative properties of the substance, its influence on organs and systems, as well as on the overall survivorship and tolerance of animals of a given substance at low or moderate doses under the conditions of its administration for 90 days. In the process of the experiment, all three studied compositions based on phytoextracts at a dose of 5 ml / kg did not show general toxicity in rats. The data obtained indicate that these test samples behave as compositions with a favorable toxicological profile, which, upon prolonged administration, do not cause common toxicological signs of harm to the health and do not cause death of experimental rats. |
