The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies
| Autor: | Rachel M. Brouwer, L D de Witte, Sanne M. Kemner, Willem A. Nolen, G. Snijders, Esther Mesman, Manon H.J. Hillegers, R. Vonk, Hemmo A. Drexhage |
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| Přispěvatelé: | Immunology, Clinical Cognitive Neuropsychiatry Research Program (CCNP) |
| Rok vydání: | 2017 |
| Předmět: |
DISORDER
Offspring Bipolar disorder Short Communication Twins Physiology DISEASE Autoimmune thyroiditis Offspring Twins 03 medical and health sciences 0302 clinical medicine ENDOPHENOTYPE Thyroid peroxidase medicine Prevalence Journal Article Biological Psychiatry biology AUTOIMMUNE-THYROIDITIS Thyroid peroxidase antibodies medicine.disease DYSFUNCTION 030227 psychiatry 3. Good health Psychiatry and Mental health Mood Mood disorders Endophenotype biology.protein Psychology 030217 neurology & neurosurgery Clinical psychology Psychopathology |
| Zdroj: | International journal of bipolar disorders, 5. Springer Open International Journal of Bipolar Disorders International Journal of Bipolar Disorders, 5:1. Springer Open International Journal of Bipolar Disorders, 5(1). SPRINGER HEIDELBERG |
| ISSN: | 2194-7511 |
| Popis: | Previous studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence’s and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (without a mood disorder) compared to controls, suggesting that TPO-Abs might be considered as vulnerability factor (trait marker) for BD development. Here we elucidate, in the same cohorts, but now after 12- and 6-year follow-up, whether TPO-abs should be considered as a ‘trait’ marker for BD. The present study aims to investigate whether TPO-Abs (1) are stable over time, (2) are associated with lithium-exposure, (3) share a common genetic background with BD and are related to psychopathology. In bipolar offspring and twins, the prevalence of TPO-Abs is stable over time (r s = .72 p |
| Databáze: | OpenAIRE |
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