Limonoids Showing Selective Toxicity to DNA Repair-Deficient Yeast and Other Constituents of Trichilia emetica
| Autor: | G. A. Hofmann, A. A. L. Gunatilaka, Michael R. Mattern, E. Dagne, V. Da S. Bolzani, David G. I. Kingston, F. L. Mccabe, Randall K. Johnson |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Magnetic Resonance Spectroscopy
DNA Repair Stereochemistry DNA repair Molecular Sequence Data Pharmaceutical Science Saccharomyces cerevisiae Spectrometry Mass Fast Atom Bombardment Pharmacognosy Mass Spectrometry Analytical Chemistry Triterpene Drug Discovery Pharmacology chemistry.chemical_classification Plants Medicinal Meliaceae biology Plant Extracts Chemistry Organic Chemistry Biological activity biology.organism_classification Triterpenes Terpenoid Yeast Carbohydrate Sequence Complementary and alternative medicine Biochemistry Trichilia emetica Molecular Medicine Ethiopia Norsteroids |
| Zdroj: | Journal of Natural Products. 61:179-184 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np9701687 |
| Popis: | Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|