CRISPR-Cas Activators for Engineering Gene Expression in Higher Eukaryotes

Autor:	Matthew H. Zinselmeier, Samuel E. Erickson, Michael J. Smanski, J. Armando Casas-Mollano
Rok vydání:	2020
Předmět:	Gene Editing Transcriptional Activation Extramural Gene Expression Review Computational biology Plants Biology Genetic engineering Yeasts Gene expression Trans-Activators Genetics Animals Humans CRISPR CRISPR-Cas Systems Gene Biotechnology
Zdroj:	CRISPR J
ISSN:	2573-1602 2573-1599
Popis:	CRISPR-Cas-based transcriptional activators allow genetic engineers to specifically induce expression of one or many target genes in trans. Here we review the many design variations of these versatile tools and compare their effectiveness in different eukaryotic systems. Lastly, we highlight several applications of programmable transcriptional activation to interrogate and engineer complex biological processes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6a37223d76d9d22baf6e0f134a1c82 https://doi.org/10.1089/crispr.2020.0064 Zobrazit plný text záznamu