Does structural neuroimaging reveal a disturbance of iron metabolism in Parkinson’s disease? Implications from MRI and TCS studies
| Autor: | Daniela Berg, Adriane Gröger |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Neurology Parkinson's disease Disturbance (geology) Ultrasonography Doppler Transcranial analysis [Iron] Iron metabolism [Parkinson Disease] Neuroimaging Substantia nigra Disease Pathogenesis metabolism [Substantia Nigra] medicine Humans ddc:610 Biological Psychiatry metabolism [Iron] medicine.diagnostic_test Parkinson Disease Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging chemistry [Substantia Nigra] Substantia Nigra Psychiatry and Mental health Neurology (clinical) methods [Neuroimaging] Psychology Neuroscience |
| Zdroj: | Journal of neural transmission 119(12), 1523-1528 (2012). doi:10.1007/s00702-012-0873-0 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-012-0873-0 |
| Popis: | A central role of iron in the pathogenesis of Parkinson's disease (PD) has been discussed for many years. Numerous studies using magnetic resonance imaging and transcranial sonography have been performed to detect alterations in tissue iron content of the substantia nigra. This manuscript reviews the findings of this still controversial issue and indicates that specific abnormalities that are suggested to be related to a disturbance of iron homeostasis may play an early role in the pathogenesis of PD. |
| Databáze: | OpenAIRE |
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