A novel maladaptive unfolded protein response as a mechanism for small bowel resection-induced liver injury

Autor:	Allie E. Steinberger, Maria E. Tecos, Hannah M. Phelps, Deborah C. Rubin, Nicholas O. Davidson, Jun Guo, Brad W. Warner
Rok vydání:	2022
Předmět:	Inflammation Liver Cirrhosis Hepatology Tumor Necrosis Factor-alpha Physiology Gastroenterology Apoptosis Endoplasmic Reticulum Stress Fibrosis Mice Inbred C57BL Mice Chemical and Drug Induced Liver Injury Chronic Physiology (medical) Unfolded Protein Response Animals Transcription Factor CHOP
Zdroj:	American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G165-G176
ISSN:	1522-1547 0193-1857
Popis:	The unfolded protein response (UPR) is a complex adaptive signaling pathway activated by the accumulation of misfolded proteins in the endoplasmic reticulum (ER). ER stress (ERS) triggers a cascade of responses that converge upon C/EBP homologous protein (CHOP) to drive inflammation and apoptosis. Herein, we sought to determine whether liver injury and fibrosis after small bowel resection (SBR) were mediated by a maladaptive hepatic ERS/UPR. C57BL/6 mice underwent 50% proximal SBR or sham operation. Markers of liver injury and UPR/ERS pathways were analyzed. These were compared with experimental groups including dietary fat manipulation, tauroursodeoxycholic acid (TUDCA) treatment, distal SBR, and global CHOP knockout (KO). At 10 wk, proximal SBR had elevated alanine aminotransferase/aspartate aminotransferase (ALT/AST) (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f697dd63755a492a538e3c1a82c4cf9 https://doi.org/10.1152/ajpgi.00302.2021 Zobrazit plný text záznamu