Altered deposition of inhaled nanoparticles in subjects with chronic obstructive pulmonary disease

Autor: Hanna Nicklasson, Jenny Rissler, Anders Gudmundsson, H Laura Aaltonen, Per Wollmer, Jonas Jakobsson, Jakob Löndahl
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
02 engineering and technology
Gastroenterology
Pulmonary function testing
In vivo study
Pulmonary Disease
Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diffusing capacity
medicine
Humans
Tissue Distribution
Respiratory system
Aged
Aerosols
Sweden
Inhalation exposure
Emphysema
lcsh:RC705-779
Lung
Inhalation
business.industry
Chronic obstructive pulmonary disease
Smoking
Respiratory disease
lcsh:Diseases of the respiratory system
Middle Aged
respiratory system
021001 nanoscience & nanotechnology
medicine.disease
Respiratory Function Tests
respiratory tract diseases
Lung deposition
medicine.anatomical_structure
Pulmonary Emphysema
030228 respiratory system
Case-Control Studies
Nanoparticles
Female
0210 nano-technology
business
Research Article
Respiratory tract
Human
Zdroj: BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-11 (2018)
BMC Pulmonary Medicine
ISSN: 1471-2466
DOI: 10.1186/s12890-018-0697-2
Popis: Background Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease. Methods Lung deposition of nanoparticles (50 and 100 nm) was measured after a 10 s breath-hold for three groups: healthy never-smoking subjects (n = 17), asymptomatic (active and former) smokers (n = 15) and subjects with chronic obstructive pulmonary disease (n = 16). Measurements were made at 1300 mL and 1800 mL volumetric lung depth. Each subject also underwent conventional lung function tests, including post bronchodilator FEV1, VC, and diffusing capacity for carbon monoxide, DL,CO. Patients with previously diagnosed respiratory disease underwent a CT-scan of the lungs. Particle lung deposition fraction, was compared between the groups and with conventional lung function tests. Results We found that the deposition fraction was significantly lower for subjects with emphysema compared to the other subjects (p = 0.001–0.01), but no significant differences were found between healthy never-smokers and smokers. Furthermore, the particle deposition correlated with pulmonary function tests, FEV1%Pred (p
Databáze: OpenAIRE
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