A Betabaculovirus-Encoded gp64 Homolog Codes for a Functional Envelope Fusion Protein
| Autor: | Bergmann Morais Ribeiro, José Luiz Caldas Wolff, Rollie J. Clem, Fernando L. Melo, Daniel M. P. Ardisson-Araújo |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
food.ingredient Lineage (genetic) viruses 030106 microbiology Immunology Granulovirus Biology Microbiology Virus 03 medical and health sciences food Virology Betabaculovirus Animals F protein Envelope (waves) Genetics Whole genome sequencing Genetic Complementation Test Virus Internalization Fusion protein Virus-Cell Interactions Lepidoptera 030104 developmental biology Insect Science Viral Fusion Proteins |
| Zdroj: | Journal of Virology. 90:1668-1672 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | The GP64 envelope fusion protein is a hallmark of group I alphabaculoviruses. However, the Diatraea saccharalis granulovirus genome sequence revealed the first betabaculovirus species harboring a gp64 homolog ( disa118 ). In this work, we have shown that this homolog encodes a functional envelope fusion protein and could enable the infection and fusogenic abilities of a gp64 -null prototype baculovirus. Therefore, GP64 may complement or may be in the process of replacing F protein activity in this virus lineage. |
| Databáze: | OpenAIRE |
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