Viral inactivation of human bone tissue using supercritical fluid extraction

Autor: Béatrice Poirier, Daniel Larzul, G. Bonel, Marie-Line Joffret, W Majewski, Jacques Fages, Y Barbier, Patrick Frayssinet
Přispěvatelé: IMT Mines Albi, IMT Mines Albi, Poudres et procédés - Ecole des Mines Albi-Carmaux, IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Bioland, BioTop Institut Pasteur
Jazyk: angličtina
Rok vydání: 1998
Předmět:
Sindbis virus
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering
viruses
Biomedical Engineering
Biophysics
Guidelines as Topic
Bioengineering
02 engineering and technology
Alphavirus
Biology
medicine.disease_cause
Virus
Biomaterials
03 medical and health sciences
medicine
Humans
Sodium Hydroxide
[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
030304 developmental biology
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
0303 health sciences
Supercritical carbon dioxide
Chromatography
Ethanol
Poliovirus
Supercritical fluid extraction
Sterilization
Femur Head
Hydrogen Peroxide
General Medicine
Carbon Dioxide
Oxidants
021001 nanoscience & nanotechnology
biology.organism_classification
Herpesvirus 1
Suid

Virology
Supercritical fluid
3. Good health
Transplantation
[SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
HIV-1
Solvents
Hip Prosthesis
Sindbis Virus
0210 nano-technology
Zdroj: Europe PubMed Central
HAL
ASAIO Journal
ASAIO Journal, Lippincott, Williams & Wilkins, 1998, 44 (4), pp.289-293
ResearcherID
ISSN: 1058-2916
Popis: 4th International Symposium on Supercritical Fluids, SENDAI, JAPAN, MAY 11-14, 1997; International audience; A new bone tissue process using supercritical carbon dioxide fluid extraction (SFE) has been evaluated for its ability to inactivate or eliminate viruses. Four viruses, human immunodeficiency virus type 1 (HIV-1), Sindbis virus, polio Sabin type I virus, and pseudorabies virus (PRV), were exposed to four different processing steps. In addition to supercritical CO2, hydrogen peroxide, sodium hydroxide, and ethanol treatments were evaluated. The mean cumulated reduction factors (log(10)) for the four viruses exposed to these four steps were >14.2 for HIV-1, >18.2 for Sindbis virus, >24.4 for poliovirus, and >17.6 for PRV. The mean reduction factors obtained by the supercritical fluid extraction alone were >4.0, >4.3, >6.6, and >4.0, respectively. These results demonstrate that the SFE process is effective in inactivating viruses on human femoral heads, and provides a level of inactivation similar to that obtained by traditional cleaning methods. It is proposed that CO2 SFE be incorporated as a routine step in the processing of bone allografts for transplantation either to replace or supplement existing procedures.
Databáze: OpenAIRE
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