Viral inactivation of human bone tissue using supercritical fluid extraction
Autor: | Béatrice Poirier, Daniel Larzul, G. Bonel, Marie-Line Joffret, W Majewski, Jacques Fages, Y Barbier, Patrick Frayssinet |
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Přispěvatelé: | IMT Mines Albi, IMT Mines Albi, Poudres et procédés - Ecole des Mines Albi-Carmaux, IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Bioland, BioTop Institut Pasteur |
Jazyk: | angličtina |
Rok vydání: | 1998 |
Předmět: |
Sindbis virus
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering viruses Biomedical Engineering Biophysics Guidelines as Topic Bioengineering 02 engineering and technology Alphavirus Biology medicine.disease_cause Virus Biomaterials 03 medical and health sciences medicine Humans Sodium Hydroxide [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials 030304 developmental biology [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology 0303 health sciences Supercritical carbon dioxide Chromatography Ethanol Poliovirus Supercritical fluid extraction Sterilization Femur Head Hydrogen Peroxide General Medicine Carbon Dioxide Oxidants 021001 nanoscience & nanotechnology biology.organism_classification Herpesvirus 1 Suid Virology Supercritical fluid 3. Good health Transplantation [SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology HIV-1 Solvents Hip Prosthesis Sindbis Virus 0210 nano-technology |
Zdroj: | Europe PubMed Central HAL ASAIO Journal ASAIO Journal, Lippincott, Williams & Wilkins, 1998, 44 (4), pp.289-293 ResearcherID |
ISSN: | 1058-2916 |
Popis: | 4th International Symposium on Supercritical Fluids, SENDAI, JAPAN, MAY 11-14, 1997; International audience; A new bone tissue process using supercritical carbon dioxide fluid extraction (SFE) has been evaluated for its ability to inactivate or eliminate viruses. Four viruses, human immunodeficiency virus type 1 (HIV-1), Sindbis virus, polio Sabin type I virus, and pseudorabies virus (PRV), were exposed to four different processing steps. In addition to supercritical CO2, hydrogen peroxide, sodium hydroxide, and ethanol treatments were evaluated. The mean cumulated reduction factors (log(10)) for the four viruses exposed to these four steps were >14.2 for HIV-1, >18.2 for Sindbis virus, >24.4 for poliovirus, and >17.6 for PRV. The mean reduction factors obtained by the supercritical fluid extraction alone were >4.0, >4.3, >6.6, and >4.0, respectively. These results demonstrate that the SFE process is effective in inactivating viruses on human femoral heads, and provides a level of inactivation similar to that obtained by traditional cleaning methods. It is proposed that CO2 SFE be incorporated as a routine step in the processing of bone allografts for transplantation either to replace or supplement existing procedures. |
Databáze: | OpenAIRE |
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