Growth Hormone (Replacement) Therapy in Adults: Bone and Calcium Metabolism
| Autor: | E.A. van der Veen, J.C. Netelenbos |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Bone mineral
Calcium metabolism medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis chemistry.chemical_element Calcium Biology medicine.disease Bone and Bones Bone resorption Bone remodeling Endocrinology chemistry Calcitonin Growth Hormone Internal medicine Acromegaly medicine Humans |
| Zdroj: | Hormone Research. 33:65-68 |
| ISSN: | 1423-0046 0301-0163 |
| DOI: | 10.1159/000181587 |
| Popis: | Calcium uptake from the gut is increased by GH effects on vitamin D metabolism or action. Bone metabolism is stimulated by many factors, of which GH and insulin-like growth factor I (IGF-I) are only two examples. From various animal and human data, it can be shown that GH and IGF-I seem to influence bone formation more than bone resorption. However, GH excess, as seen in acromegaly, does not result in increased bone mass. GH was used to treat osteoporosis in a few clinical trials. In only one, in combination with calcitonin, an increase in bone mass was observed. In GH-deficient adult patients, substitution therapy resulted in a temporary increase in serum calcium levels. Effects on bone mineral mass were only found in a pilot study performed by us in a group of 8 GH-deficient adult patients. The mean increase of bone mineral mass was 0.04 g hydroxyapatite/cm2, p less than 0.05. These data indicate that GH substitution can result in increased bone mass. |
| Databáze: | OpenAIRE |
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